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The signature 
 of a Knot 
 can be defined using the Skein Relationship
Many Unknotting Numbers can be determined using a knot's signature.
See also Skein Relationship, Unknotting Number
References
Gordon, C. McA.; Litherland, R. A.; and Murasugi, K.  ``Signatures of Covering Links.''  Canad. J. Math. 33, 381-394, 1981.
 
Murasugi, K.  ``On the Signature of Links.''  Topology 9, 283-298, 1970.
 
Murasugi, K.  ``Signatures and Alexander Polynomials of Two-Bridge Knots.''  C. R. Math. Rep. Acad. Sci. Canada 5,
  133-136, 1983.
 
Murasugi, K.  ``On the Signature of a Graph.''  C. R. Math. Rep. Acad. Sci. Canada 10, 107-111, 1988.
 
Murasugi, K.  ``On Invariants of Graphs with Applications to Knot Theory.'' Trans. Amer. Math. Soc. 314, 1-49, 1989.
 
Rolfsen, D.  Knots and Links.  Wilmington, DE: Publish or Perish Press, 1976.
 
Stoimenow, A.  ``Signatures.''  http://www.informatik.hu-berlin.de/~stoimeno/ptab/sig10.html.